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Describes the medication methotrexate (Trexall, Rheumatrex) a drug used in treating certain diseases associated with abnormally rapid cell growth. Article includes descriptions, uses, drug interactions, and side effects.
Rheumatrex - Clinical Pharmacology. Methotrexate inhibits dihydrofolic acid reductase. Dihydrofolates must be reduced to tetrahydrofolates by this enzyme before they can be utilized as carriers of one-carbon groups in the synthesis of purine nucleotides and thymidylate.
Methotrexate is one of the most effective and commonly used medications in the treatment of rheumatoid arthritis and other forms of inflammatory arthritis, and also may be used to treat lupus, inflammatory myositis, vasculitis, and some forms of childhood arthritis.
Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Learn about side effects, interactions and indications.
Extra care is needed because methotrexate is a high-alert medicine. High-alert medicines have been proven to be safe and effective. But these medicines can cause serious injury if a mistake happens while taking them.
Trexall is the brand name of methotrexate sodium, a drug prescribed to treat psoriasis and rheumatoid arthritis. It can also treat neoplastic diseases, or diseases that result from the abnormal growth of tissue, such as gestational choriocarcinoma, chorioadenoma destruens, and hydatidiform mole.
Summary. Methotrexate side effects may include and are not limited to mouth sores, vomiting, hair loss, and nausea. More serious side effects can include jaundice and kidney toxicity.
Alkaloid-containing plants have been used by humans since ancient times for therapeutic and recreational purposes. For example, medicinal plants have been known in the Mesopotamia at least around 2000 BC. The Odyssey of Homer referred to a gift given to Helen by the Egyptian queen, a drug bringing oblivion.
Methotrexate is used to treat severe psoriasis (a skin disease in which red, scaly patches form on some areas of the body) that cannot be controlled by other treatments.
Methotrexate is an antimetabolite of the antifolate type. It is thought to affect cancer and rheumatoid arthritis by two different pathways. For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis.