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Reteplase (trade names Retavase, Rapilysin) is a thrombolytic drug, used to treat heart attacks by breaking up the clots that cause them. Reteplase is a recombinant non-glycosylated form of human tissue plasminogen activator, which has been modified to contain 357 of the 527 amino acids of the original protein.
Easy-to-read patient leaflet for Reteplase. Includes indications, proper use, special instructions, precautions, and possible side effects.
Medscape - Indication-specific dosing for Retavase (reteplase), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
Retavase® (reteplase, recombinant) Lyophilized Powder for Intravenous Bolus Injection. DESCRIPTION. Retavase® (Reteplase) is a non-glycosylated deletion mutein of tissue plasminogen activator , containing the kringle 2 and the protease domains of human tPA.
PLAT A gene on chromosome 8p12 that encodes tissue plasminogen activator, which converts inactive plasminogen to plasmin by hydrolysing a single Arg-Val bond in plasminogen, thereby playing a key role in tissue remodelling, degradation, cell migration and other cellular events.
Reteplase is a thrombolytic (THROM-bo-LIT-ik) drug that is used to dissolve blood clots. Reteplase is used to improve heart function and prevent congestive heart failure or death in people who have had a heart attack.
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Reteplase. Reteplase is the first third-generation thrombolytic agent to be approved for use in acute MI to improve postinfarct ventricular function, lessen the incidence of congestive heart failure, and reduce mortality.35
Along with its needed effects, reteplase may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur while taking reteplase: Hematologic
Drug information on Retavase (retaplase), includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid.